HBV is a DNA virus. Eight genotypes of HBV have been identified and labeled A through H, Genotype D being most common in pakistan. I tried to compile key points from AASLD management guidelines. Taking treatment decision requires concept of different phases of chronic Hepatitis B infection so first we will discuss these four phases and then key points for the management of chronic hepatitis B infection.
Phases Of Chronic Hepatitis B Infection:
Chronic Hep B:
◦Positive for the hepatitis B virus (HBsAg) for more than six months
There are four Phases Of Chronic Hep B Infection
1. Immune tolerant Phase
2. Immune active Phase:
3. Inactive (Immune Control) Phase:
4. Immune Escape Phase:
Indications for treatment:
◦clearance of HBV DNA
◦normalization of liver enzymes.
Duration Of Treatment:
Hepatitis B in pregnancy:
There is either HBV dominance, which means high HBV DNA levels and low HCV RNA levels or HCV dominance defined by the high HCV RNA levels and low HBV DNA.
HBV Dominance – treat HBV
HCV Dominance – treat HCV
AASLD Guidelines: American Association for the Study of Liver Diseases
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